Allowing Maher to offer his unique perspective on contemporary issues, the show includes an opening monologue, roundtable discussions with panelists and interviews with guests. Dr. Anne Rimoin, Associate Professor of Epidemiology at UCLA and Director of the Fielding School's Center for Global and Immigrant Health is the top-of-show interview guest. Pulitzer Prize-winning New York Times columnist Nicholas Kristof is the mid-show interview guest. The roundtable guests are The Washington Post columnist and New York Times bestselling author E.J. Dionne, author and Nebraska Democratic Party Chair Jane Kleeb and former CIA officer and radio host Buck Sexton.