"Change" is the name of the game for everyone in the 4th Season Opener as the Botwin family, homeless since their beloved town of Majestic has burned down, hits the road in search of a new place to call home and of course, grow Weed. Their leaving is right on time, as relentless DEA Capt. Roy Till continues to hunt for whomever is responsible for the temporary grow house, now abandoned by Conrad and Heylia. With all the real players gone, everyone fingers Celia as the culprit, but she points to Nancy; the family heads to Del Mar, where Andy's grandmother lives, but no one is happy to learn Andy's father is in charge; Guillermo offers Nancy a new opportunity in a much riskier end of the drug business.