The Gaines Twins, Roxanne and Roland have brain-blasted Spider-Man into believing that Mary-Jane Watson has died at the hands of Kraven the Hunter. Convinced by Frank Elson, a mysterious stranger, that the only solace is revenge, Spider-Man now tracks down Kraven in order to pay him the identical fate he inflicted on MJ. Part Two begins with Kraven drawing his final breaths under Spider-Man's might. Moments from delivering Kraven the final blow, Spider-Man notices that the surroundings don't mesh with some of his more recent memories. Combine that with a few of Kraven's conflicting syllables and Spider-Man determines that his reality has somehow been tampered with. The questions is, how or more like by whom? The Gaines Twins are behind everything and while Spider-Man seeks them out to confront them. During the confrontation it looks like Spider-Man is winning as he frees MJ from their grasp. Things take a turn for the worse when the twins use their mental power to trick Spider-Man into harming Indy. After this, the chatter (along with the rest of New York's sentiment) is all anti-Spider-Man and unfortunately a grief stricken Peter Parker agrees. This leaves Spider-Man one last obligation. He tracks down The Gaines Twins at a propane factory where their end is nothing short of explosive. Lastly, a spiritless, dejected, and morose Peter Parker tightly packs up his Spider-Man suit and throws it into the Hudson River allowing it to sink into the murky depths. Is this the end of Spider-Man? Or a new beginning for Peter Parker?