Down For Whatever chronicles Tracy, a young successful doctor and her detective husband, Mike. Although happily married, one thing has always been missing in their relationship - a sense of family. Tracy grew up in foster care and longs for the traditional family environment that she never had. When Mike suddenly loses his partner in a senseless cop-killing, Tracy is there to support him. That is, until she receives an unexpected visit from a social worker who informs her that the ruthless killers suspected in the murder are her biological sisters, Denise and Sonya. Tracy is overwhelmed and in disbelief by the news, but before telling her husband, she decides to track her sisters down herself.