Curtis, an American man looking for an escape to nature, joins his estranged Brazilian biologist brother Francis on a spontaneous journey to find a rare beetle in the Amazon. While hiking, Curtis is bitten by a snake. As he enters a hallucinogenic state from the venom, the two brothers are captured as slaves by a tribe of Amazonian women. Under the control of a princess slave-master Osimao, Curtis enters a matriarchal society where women prepare to cannibalize Francis and turn Curtis into a sex-slave-warrior. In confinement, Curtis befriends Cobrao, another male slave. Together they plot the rescue of Francis, and their own escape.